Dialogue between estrogen receptor and E2F signaling pathways: The
By A Mystery Man Writer
Description
Estrogen receptors and E2F transcription factors are the key players of two nuclear signaling pathways which exert a major role in oncogenesis, particularly in the mammary gland. Different levels of dialogue between these two pathways have been deciphered and deregulation of the E2F pathway has been shown to impact the response of breast cancer cells to endocrine therapies. The present review focuses on the transcriptional coregulator RIP140/NRIP1 which is involved in several regulatory feed-back loops and inhibitory cross-talks between different nuclear signaling pathways. RIP140 regulates the transactivation potential of estrogen receptors and E2Fs and is also a direct transcriptional target of these transcription factors. Published data highlight the complex regulation of RIP140 expression at the transcriptional level and its potential role in transcription cross-talks. Indeed, a subtle regulation of RIP140 expression levels has important consequences on other transcription networks targeted by this coregulator. Another level of regulation implies titration mechanisms by which activation of a pathway leads to sequestration of the RIP140 protein and thus impinges other gene regulatory circuitries. Altogether, RIP140 occupies a place of choice in the dialogue between nuclear receptors and E2Fs, which could be highly relevant in various human pathologies such as cancer or metabolic diseases.
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://content.kopykitab.com/ebooks/2016/02/15727/content/medium/page3.png)
Free Download Dialogue Between Estrogen Receptor And E2F Signaling
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://www.ncbi.nlm.nih.gov/books/NBK279171/bin/glucocort-receptor-Image015.jpg)
Glucocorticoid Receptor - Endotext - NCBI Bookshelf
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://www.researchgate.net/publication/23448595/figure/fig1/AS:601659537358866@1520458220407/An-FSH-analogue-superactivates-ER-transcriptional-activity-via-PKA-signaling-in-KGN.png)
An FSH analogue superactivates ER transcriptional activity via PKA
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://www.cusabio.com/statics/images/pathway/Estrogen-signaling-pathway-picture.png)
Estrogen signaling pathway - Cusabio
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://media.springernature.com/lw367/springer-static/image/art%3A10.1007%2Fs00432-021-03722-3/MediaObjects/432_2021_3722_Fig2_HTML.png?as=jpg)
The mechanisms involved in the resistance of estrogen receptor
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://content.kopykitab.com/ebooks/2016/02/15727/content/medium/page7.png)
Free Download Dialogue Between Estrogen Receptor And E2F Signaling
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://d3i71xaburhd42.cloudfront.net/5fec96151b6bda39090d94863d302018f32d6617/10-Figure2-1.png)
Mechanisms and significance of nuclear receptor auto- and cross-regulation.
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://www.researchgate.net/publication/374682874/figure/fig3/AS:11431281210579743@1702055694936/Illustration-of-low-A-D-G-J-moderate-B-E-H-K-or-marked-C-F-I-L-inflammation-in_Q320.jpg)
Vincent CAVAILLÈS, French Institute of Health and Medical Research, Inserm, Montpellier Cancer Research Institute IRCM
Estrogen Signaling Pathway - Creative Diagnostics
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://onco-hema.healthbooktimes.org/article/24833-breast-cancer-treatment-in-the-era-of-precision-medicine/attachment/62967.png)
Breast Cancer Treatment in the Era of Precision Medicine
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://www.researchgate.net/profile/Shigeaki-Kato-2/publication/23448595/figure/fig3/AS:601659537358871@1520458220478/GIOT-4-and-human-SWI-SNF-complex-components-were-recruited-to-consensus-ERE-like-elements_Q320.jpg)
GIOT-4 and human SWI/SNF complex components were recruited to consensus
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://ars.els-cdn.com/content/image/1-s2.0-S1526820916302348-gr1.jpg)
Consequences of the Convergence of Multiple Alternate Pathways on
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/MAPKpathway_diagram.svg/220px-MAPKpathway_diagram.svg.png)
MAPK/ERK pathway - Wikipedia
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://www.researchgate.net/publication/360340923/figure/fig1/AS:1160168129740800@1653617045352/RIP140-deficiciency-promotes-cell-proliferation-and-tumorigenesis-a-b-Cell_Q320.jpg)
Stéphan Jalaguier's research works Institut de Recherche en Cancerologie de Montpellier, Montpellier and other places
![Dialogue between estrogen receptor and E2F signaling pathways: The](https://europepmc.org/articles/PMC3962223/bin/nihms-489031-f0004.jpg)
Regulation of estrogen receptor signaling in breast carcinogenesis
from
per adult (price varies by group size)